Level up your patients’ potential
Reimagining the way we treat ADHD
ADHD is one of the most common neurodevelopmental disorders in childhood¹. And while understanding of ADHD has grown over time, reliance on pharmacotherapy hasn’t changed in decades.
EndeavorRx treatment represents a needed shift — by introducing a nonpharmacologic approach to pediatric ADHD that may complement multifaceted treatment.
A transformative approach
EndeavorRx is a digital therapeutic indicated to improve attention function as measured by computer-based testing in children ages 8-12 years old with primarily inattentive or combined-type ADHD. It’s the first and only FDA-authorized treatment of its kind, evaluated in over 600 children with ADHD across 5 clinical studies.²
Patients who engage with EndeavorRx demonstrate improvements in a digitally assessed measure, Test of Variables of Attention (TOVA®)³, of sustained and selective attention and may not display benefits in typical behavioral symptoms, such as hyperactivity.
EndeavorRx should be considered for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder.Learn More About Efficacy
¹ Centers for Disease Control and Prevention (CDC). What is ADHD? Accessed June 17, 2021. https://www.cdc.gov/ncbddd/adhd/facts.html
² Kollins et al, Lancet Digital Health, 2020. Kollins et al, npj digital medicine, 2021. Proof of concept study: Davis et al, PLOS One, 2018. Pilot studies: Anguera et al., PLOS One, 2017. Yerys et al., J Autism Dev Disord, 2019
³ The TOVA® – Test of Variables of Attention – is an FDA-authorized objective, computerized continuous performance test measuring attention and inhibitory control, and can aid in the diagnosis and treatment evaluation of ADHD.
Improving attention and capturing imaginations
EndeavorRx is designed to improve attentional control by strengthening focus, interference processing and multitasking. This helps to achieve goals, as well as minimize interruptions, distractions, and irrelevant information.
This is enabled by our Selective Stimulus Management Engine (SSME™) — the highly responsive technology behind EndeavorRx’s gameplay design.
How does SSME Technology work?
Our Selective Stimulus Management Engine (SSME) is a proprietary technology that presents specific sensory stimuli and simultaneous motor challenges designed to target key neural systems in the brain related to attentional control.
Algorithms adapt in real-time and between treatment sessions to automatically adjust the difficulty level, allowing for second-by-second monitoring of patient progress.
The game layer built on top of the technology was designed to create a fun, age-appropriate experience, using built-in game rewards, missions, levels, and storytelling to help support the child to stay engaged with their treatment.
Unlike most video games, the amount of time patients play is limited to a certain “dose” for each session — which comes to an end once they’ve reached their daily goal.
What’s it like to play?
When using EndeavorRx, players attempt to successfully navigate their character through courses while collecting targets and avoiding obstacles. They’ll chase mystic creatures, racing through different worlds, using boosts to problem-solve while building their very own universe.
Successfully navigating each level requires focus and flexibility to manage multiple tasks at the same time, while filtering out distractions — and the difficulty level adapts in real-time to continuously challenge each child.
See EndeavorRx in action
Watch our gameplay trailer or download a 5-minute demo from the App Store® or on Google Play™ to try it for yourself.
Download a demo version of the app
Note: as the demo is designed to be non-therapeutic it should not be used as a substitute for the actual EndeavorRx treatment. A compatible Apple® or Android™ device is needed to play the demo.
Follow their treatment journey with EndeavorRx Insight®
Our free companion app for parents connects directly to their child’s EndeavorRx treatment, so they can get a daily snapshot of their in‑game progress.
Parents can check‑in to see if their child has completed all of their play for the day.
By analyzing in‑game interactions, we calculate a daily score to give parents a sense of their child’s level of effort and if their child is playing with the correct rules.
Having an issue? The app can help connect parents to our Akili Assist® support team.
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Indications, Safety and Cautions
EndeavorRx is a digital therapeutic indicated to improve attention function as measured by computer-based testing in children ages 8-12 years old with primarily inattentive or combined-type ADHD, who have a demonstrated attention issue. Patients who engage with EndeavorRx demonstrate improvements in a digitally assessed measure, Test of Variables of Attention (TOVA®), of sustained and selective attention and may not display benefits in typical behavioral symptoms, such as hyperactivity. EndeavorRx should be considered for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder.
Of 538 participants using EndeavorRx, 50 participants (9.3%) experienced treatment-related adverse events (probable, likely), and three participants experienced treatment-related adverse events with the digital control, in studies where a control was used. EndeavorRx associated adverse events included frustration (6.1%), headache (1.3%), dizziness (0.6%), emotional reaction (0.4%), nausea (0.4%), and aggression (0.2%). There were no serious adverse events. All adverse events were generally transient. Only 3 events led to device discontinuation, and no subject reported lasting or irreversible effects after discontinuation.
Rx only: Federal law restricts this device to sale by or on the order of a physician. EndeavorRx should only be used by the patient for whom the prescription was written. For medical questions, please contact your child’s healthcare provider. If you are experiencing a medical emergency, please dial 911. EndeavorRx is not intended to be used as a stand-alone therapeutic and is not a substitution for your child’s medication.
If your child experiences frustration, emotional reaction, dizziness, nausea, headache, eye-strain, or joint pain while playing EndeavorRx pause the treatment. If the problem persists contact your child’s healthcare provider. If your child experiences a seizure stop the treatment and contact your child’s healthcare provider.
EndeavorRx may not be appropriate for patients with photo-sensitive epilepsy, color blindness, or physical limitations that restrict use of a mobile device; parents should consult with their child’s healthcare provider.
Please follow all of your mobile device manufacturer’s instructions for the safe operation of your mobile device. For example, this may include appropriate volume settings, proper battery charging, not operating the device if damaged, and proper device disposal. Contact your mobile device manufacturer for any questions or concerns that pertain to your device.